Monday, 2 July 2012

Verapress MR 240 Tablets






VERAPRESS
MR 240 Tablets



Verapamil Hydrochloride



Please read this leaflet carefully before you start taking your tablets.


  • Keep this leaflet. You may need to read it again.

  • This leaflet provides some useful information for you about your medicine.

  • If you have any questions or are not sure about anything ask your doctor or pharmacist.


REMEMBER: This medicine has been prescribed for you. Do not pass it to others. It may harm them, even if their symptoms are the same as yours.




In this leaflet:


  • 1. What Verapress MR 240 Tablets are and what they are used for

  • 2. Before you take Verapress MR 240 Tablets

  • 3. How to take Verapress MR 240 Tablets

  • 4. Possible side effects

  • 5. How to store Verapress MR 240 Tablets

  • 6. Further information




What Verapress Mr 240 Tablets Are And What They Are Used For



The name of your medicine is: Verapress MR 240 Tablets


Verapress MR 240 Tablets belong to a group of medicines called calcium channel blockers. Calcium channel blockers change the amount of calcium getting into the muscle cell in your heart and blood vessels. This can change the strength and speed with which your heart beats. It also opens up the blood vessels so blood can be pumped around the body more easily. This helps more oxygen to get to your heart muscle and can lower your blood pressure.


Verapress MR 240 Tablets are indicated for the treatment of mild to moderate hypertension (high blood pressure) and the treatment and prevention of angina pectoris (chest pain).




Before You Take Verapress Mr 240 Tablets



If you are unsure if any of the lists applies to you, ask your doctor before you start to take your tablets.



Do not take Verapress MR 240 Tablets:


  • If you are allergic to Verapamil Hydrochloride or to any of the other ingredients of Verapress MR 240 Tablets (listed in section 6 - Further information).

  • If you are having a cardiogenic shock (a sudden and rapid fall in blood pressure).

  • If you are having or have recently had a heart attack particularly if a slow heart beat, low blood pressure or left ventricular failure of the heart are involved.

  • If you have second or third degree atrioventricular block or sino-atrial block (a disorder where parts of the heart may beat at the wrong time causing the heart not to pump blood around the body very well).

  • If you have sick sinus syndrome (a heart beat disorder).

  • If you have heart failure that is not currently being treated.

  • If you have severe bradycardia (a condition where the heart beats at less than 50 beats per minute).

  • If you have low blood pressure where the higher blood pressure reading is below 90.

This medicine is for adults only. It should not be given to children under the age of 12.




Take special care with Verapress MR 240 Tablets:


Consult your doctor or pharmacist if:


  • You suffer or you have ever suffered in the past from low blood pressure, from a condition known as "heart failure", an abnormally slow or irregular heart beat, or any other cardiac problem including Wolff-Parkinson-White syndrome.

  • You suffer or you have ever suffered in the past from kidney or liver disorders. These above mentioned medical conditions may mean that your doctor will need to monitor you more closely.

  • You are planning to have medical or dental surgery. This medicine may affect the anaesthetics or other treatments used.



Taking other medicines:


Please inform your doctor or pharmacist if you are taking or have recently taken any of the following medicines, even those not prescribed:


  • Digoxin (used to treat certain heart conditions, such as heart failure)

  • Beta-blockers or any other treatment for heart diseases and high blood pressure

  • Anti-arrhythmic agents (used to steady an irregular heart beat)

  • Carbamazepine, Phenytoin, Phenobarbital (usually used in epilepsy)

  • Ciclosporin (normally used following organ transplants to help prevent rejection)

  • Theophylline (used for breathing difficulties e.g. asthma)

  • Rifampicin (antibiotic action for treatment of various infections such as tuberculosis (TB))

  • Lithium (used for psychiatric conditions)

  • Cimetidine (used for stomach disorders e.g. ulcers)



Taking Verapress MR 240 Tablets with food and drink:


Verapress MR 240 Tablets will increase the time your body takes to get rid of alcohol. This means that you may not have to drink as much for your blood alcohol level to be above the legal limit to drive. It will also take you longer to sober up.



Do not drink products containing grapefruit juice at the same time as you take this medicine.




Pregnancy and breast-feeding:


Consult your doctor or pharmacist if you are pregnant, trying to become pregnant, or breast-feeding.




Driving and using machines:


Verapress MR 240 Tablets can make some people feel dizzy especially when first starting to take the tablets. Do not drive, operate machinery or do anything that requires you to be alert, until you know how the tablets affect you.




Important information about some of the ingredients of Verapress MR 240 Tablets:


This medicinal product contains 36 mg sodium per dose. To be taken into consideration by patients on a controlled sodium diet.





How To Take Verapress Mr 240 Tablets


Always take Verapress MR 240 Tablets exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure.



The tablets should not be chewed. They should be swallowed whole with a glass of water.



  • For treatment of hypertension: The usual dosage is one tablet per day. Some patients may need to take two tablets per day (one in the morning and one in the evening with about 12 hours between doses). Do not take more than two tablets per day.


  • For the treatment and prevention of angina pectoris: The usual dose is one tablet twice daily.


If you take more Verapress MR 240 Tablets than you should


In case of an overdose, contact your nearest hospital casualty department or tell your doctor immediately.




If you forget to take Verapress MR 240 Tablets


If you forget to take a dose, take it as soon as you remember, unless it is almost time for your next dose. If it is, do not take the missed dose at all. Never double-up on a dose to make up for the one you have missed.


If you have trouble remembering to take your tablets, tell your doctor or your pharmacist. If you take too many tablets by mistake, any side effects (see below) may be worse than usual; in this case see your doctor.




If you stop taking Verapress MR 240 Tablets


It is important that you continue taking the tablets until your doctor tells you to stop.


Do not stop because you feel better. If you stop taking the tablets too soon your condition may get worse.





Possible Side Effects


Verapress MR 240 is generally well tolerated. Side effects are usually mild and transient.


In rare cases people may have an allergic reaction to Verapamil Hydrochloride. You should tell your doctor immediately if you have any unexpected wheezing or difficulty in breathing, if you have Quincke's oedema (swelling of the face with itching), swelling of the mouth, lips, or tongue, or if you develop a skin rash, pruritus (itching), or severe skin rash with blistering and peeling of the skin.



If you experience the following side effects you should tell your doctor immediately:


  • If you develop yellowing of the skin or eyes, a fever or tenderness around the middle.

  • If you have bradycardia (slow heart beats), arrhythmia (irregular heart rhythm), palpitations (awareness of an irregular or rapid heart beat),heart failure, reversible impairment of liver function, chest pains for the first time or chest pains that become more frequent, dizziness, weakness or confusion, swollen ankles, feeling faint or breathless or a burning sensation in the feet, which may become hot and throbbing.

  • Hypotension (abnormally low blood pressure)



Do not stop taking the tablets, but tell your doctor if you get any of the following:


Digestive effects such as constipation, nausea (feeling sick) or vomiting, headache, flushing, fatigue, pins and needles, muscle and joint pain.


Swelling of the breasts (gynaecomastia), which is usually seen in elderly male patients, and spreading of the gums over the teeth can occur with long term treatment. These effects are very rare and resolve on stopping treatment. You should tell your doctor if these side effects appear.




If you think your medicine may be causing any problems, even if they are not described in this leaflet, tell your doctor or pharmacist.




How To Store Verapress Mr 240 Tablets


Keep out of the reach and sight of children.


Check the expiry date on the label. Do not use the tablets if the date has passed.


You should store the tablets at or below 25°C.


In case of visible signs of deterioration, you should discard the package.


Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.




Further Information



What Verapress MR 240 Tablets contain:



The active substance is: Verapamil Hydrochloride 240mg.



The other ingredients are: Core: Sodium alginate, Microcrystalline cellulose, Povidone, Hypromellose, Colloidal anhydrous silica, Magnesium stearate.


Coating: Hypromellose, Titanium dioxide, Macrogol, Yellow Lake E-104, Blue Lake E-132 and Carnauba wax.




What Verapress MR 240 Tablets look like and content of the pack:


This medicine can be identified as modified release, light-green film-coated, capsule-shaped, scored tablets.


Verapress MR 240 Tablets are supplied in packs of 28 tablets.




The Manufacturer/Holder of Marketing Authorisation is:



Dexcel - Pharma Ltd

1 Cottesbrooke Park

Heartlands Business Park

Daventry

Northamptonshire

NN11 8YL

England





Date upon which the leaflet was last revised: November 2008


1290603115-E





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